心脏常驻巨噬细胞是自我维持的,心肌梗塞 (MI) 后心脏驻留巨噬细胞负责有效清除和降解凋亡心肌细胞(efferocytosis,胞葬作用)。这个过程是炎症消退和组织修复所必需的;然而,潜在的分子机制仍然未知。因此,该研究旨在确定在 MI 期间心脏驻留巨噬细胞持续清除和降解吞噬溶酶体货物的机制。
2022年4月18日,复旦大学葛均波团队在Circulation(IF=30)在线发表题为“Cardiac Resident Macrophage-derived Legumain Improves Cardiac Repair via Promoting Clearance and Degradation of Apoptotic Cardiomyocytes after Myocardial Infarction”的研究论文,该研究将legumain (Lgmn) 鉴定为由心脏常驻巨噬细胞特异性表达的基因。
1.Daile Jia,etal.Cardiac Resident Macrophage-derived Legumain Improves Cardiac Repair via Promoting Clearance and Degradation of Apoptotic Cardiomyocytes after Myocardial Infarction.CIRCULATIONAHA.121.057549Circulation. 2022;0
2.Lihong Pan,etal.Legumain Is an Endogenous Modulator of Integrin αvβ3 Triggering Vascular Degeneration, Dissection,andRupture.CIRCULATIONAHA.121.056640Circulation. 2022;145:659–674