肠道菌群的改变是酒精性脂肪肝的主要病因之一

Title:
Altered intestinal microbiota as a major driving force in alcoholic steatohepatitis

Abstract：
Alcoholic hepatitis (AH) covers a spectrum of disease severities from subclinical liver inflammation to acute liver failure. Among the histological features of alcoholic liver disease (ALD), AH is associated with the highest risk of fibrosis progres- sion, leading to development of cirrhosis in 40% of cases. Patients hospitalised for severe forms of AH show 1-month mortality rates of 40–50%. Patients with AH form a heterogeneous population, in severity, and probably in disease pathogenesis. This diverse clinical picture might be caused by various factors including host factors, immunity and as recently suggested, intestinal microbiota (IM).

All Authors:
Tilg H, Mathurin P

First Authors:
Herbert Tilg

Correspondence:
Herbert Tilg，Philippe Mathurin

DOI:
10.1136/gutjnl-2015-311014